Ionic medicine has gained considerable attention for its applications in bone regeneration, wound healing and skeletal muscle repair, but its role in cartilage regeneration remains relatively unexplored. However, literature suggests that lithium ions have great potential to promote cartilage repair in vitro and in vivo. These studies demonstrate that Li enhances cartilage extracellular matrix (ECM) production in vitro and protects cartilage from inflammatory induced degradation in vitro and in vivo. Optimal therapeutic Li concentrations differ based on the desired biological response: while lower concentrations (5 - 10 mM) can stimulate ECM production, higher concentrations (10 - 50 mM) promote anti-inflammatory effects. This means that immediately after the implantation of a cartilage scaffold, a high Li concentration is required to reduce surgery- or osteoarthritis depended inflammation, while a prolonged release of low Li concentrations is needed to support sustained ECM stimulation. In this work, Li-doped MBGNs are synthesized by applying a previously established protocol with modifications, which leads to spherical nanoparticles with homogeneous size of 100 nm in average. Furthermore, the release behavior of Li ions from various hybrid biomaterials, including Li-doped MBGNs, LiCl-ADA-GEL capsules, and 3D-printed (LiCl-)ADA-GEL scaffolds, where Li-doped MBGNs are incorporated as BIFs are evaluated. Additionally, to investigate the stimulatory effects of Li ions on chondrocytes in vitro, ACDT5 cells are analysed in terms of the expression of chondrocyte-specific genes, including SOX9, Aggrecan, and Collagen Type II.