Due to the growing share of volatile renewable electricity production, the requirement profile for gas power plants is changing from base to peak load. Because of the excellent quick-start properties of stationary gas turbines, they are well suited to compensate the high fluctuations of electricity demand. This results in a new complex requirement profile with simultaneously high demands for reliability of the individual gas turbine components.In stationary gas turbines, polycrystalline nickel-based superalloys are used as turbine blade material. To ensure high reliability, a profound understanding of the fatigue behaviour of the materials under high mechanical loads is essential. Therefore, the influence of grain orientation on the deformation and damage behaviour of a polycrystalline nickel-based superalloy was investigated.