Joining titanium alloys with other metals is a major problem due to titanium's propensity to form brittle intermetallic phases with most of the metals commonly used for engineering alloy components. Joints between aluminum alloys and titanium alloys are of high interest to researchers because of the low density of both alloys and their good corrosion resistance. The use of joints of this type helps meet the requirement for high strength and low weight of structures, for example in the aerospace or automotive industries. Challenges in joining aluminum and titanium alloys arise from the formation of brittle Al/Ti intermetallic phases and differences between the two metals, such as thermal conductivity, coefficient of thermal expansion and melting point. Because of its high metallurgical purity, high precision, power and wide range of modifiable parameters, electron beam welding is one of the best methods for joining these two groups of materials. In the present study, grade 2 titanium alloy and 6082 aluminum alloy in various configurations were joined using an electron beam. The materials were joined by melting the edges of the two sheets in the appropriate ratio using beam oscillation, and also with melting of only the aluminum side with and without the addition of additional material in the form of AlSi12 wire. The obtained joints were subjected to metallographic tests on light and scanning electron microscopy, as well as tensile strength and microhardness tests. It was possible to obtain joints with satisfactory properties reaching up to 200 MPa, which is 66% of the nominal strength of Al6082 T6 alloy. By using high melting speeds, it was possible to significantly reduce the growth of intermetallic phases, ensuring favorable joint properties.