For materials with high oxygen affinity, oxide layers will significantly change the material properties. At aluminum surfaces, an oxide layer may form in seconds, even under vacuum conditions. Recent studies show that thin amorphous oxide shell layers on aluminum surfaces significantly change the responses of the material. However, the relations between the thickness of the oxidized layer, the temperature and the mechanical response of nanowires have not been investigated intensively. In this study, we use a ReaxFF potential to analyze the influences of oxide shell layers on the material responses of the nanowires under uniaxial loading at different strain rates. The Al-O interface leads to an increased defect nucleation rate at the oxide interface preventing localized deformation.