An efficient utilization of energy is important for a sustainable and carbon-emission free future. A promising technology are solide oxide fuel cells (SOFCs), which enable the conversion of chemically stored energy to electrical energy at a very high level of efficiency and a negligible amount of pollutants. Widespread application of SOFCs is currently hindered by the limited lifetime of the cells, which require maintenance or replacement at regular intervals. One main factor limiting the lifetime constitutes structural changes on the microscale in, for instance, the fuel-cell anode.To gain a deeper understanding of the underlying mechanisms which are responsible for the microstructural degradation, a multiphase-field model including interfacial diffusion is developed and simulation studies of Ni-YSZ solide-oxide fuel cell anodes are conducted. FIB-SEM reconstruction of the anode in a Ni-YSZ solid-oxide fuel cell is performed to deliver the initial microstructure for the simulations. Correlations between microstructural and electrochemical properties are established through an existing transmission-line model.