The immune system comprises molecules, cells, tissues and organs in charge of defending the organism from extrange substances, including pathogens, chemicals, neoantigens and damaged cells for destruction by means of an immune response. The initial immune response is a coordinated and sequential process carry out by immune components of the innate immune system during the immediate hours and days following recognition of the extrange molecule. The innate immunity is characterized by the presence of genetically codified invariable receptors whose ligands are evolutionary preserved, by not generating immune memory and by not generating higher intensity responses following later encounters with the same substance. The innate immune response exercises its function by developing an inflamatory response and by inhibiting viral replication in case of viral infections. When a strange substance is recognized by tissue resident immune cells, these cells synthesize and release inflamatory citokines in order to develope an acute inflamatory reaction. The acute inflamatory reaction is characterized by activation of vascular endothelium that irrigate the affected tissue, increasing vascular permeability that triggers plasma, plasma proteins and leokocytes extravasation from blood. Inability of eliminating a strange substance or inability to stop the immune response due to immune tolerance failure would give rise to tissue chronic inflamation. Chronic inflamation is characterized by leukocyte infiltration that causes tissue remodeling, angiogenesis and fibrosis with loss of phisiologic properties and function. Due to undesirable consequences of developing an immune response againts exogen substances into tissues, its compulsory to elucidate that prosthesis materials do not elicit immune responses. The aim of this research is to determine if zinc foam is a human biocompatible prosthesis material by not eliciting inflamatory citokines synthesis in blood cells culture of healthy individuals samples