Instant curing adhesives typically fall within two categories, being activated by either heat or chemical means. These curing strategies limit applications to specific substrates and can only be activated under limited certain conditions. A significant need exists for adhesives that allow for manipulation and subsequent adhesive activation in wet or low temperature surfaces.  Herein, we present the development of an instant curing adhesive through photo- or low voltage activation that allows tissue repair and dynamic in situ drug delivery.  The photocuring and electrocuring drug depots are synthesized by grafting carbene precursors on biomacromolecules to yield viscous liquids. The adhesives are activated at low UV intensities (1-50 mW. cm-2) or voltages (<10V) with material properties tuned to the soft tissue elasticity. Crosslinking initiation and propagation are observed to be stimulus and time dependent, enabling tuning of both elasticity and adhesive strength.  Adhesion bond strengths of various drug depots are demonstrated for both muscular and oral-mucosa soft tissues.