Biomedical implants used in artificial joints are known to be subjected to the combined action of mechanical loading in a reactive environment, the synovial fluid. This tribocorrosion mechanism is the responsible for the degradation of implants in-vivo and requires for understanding and identifying the key parameters affecting the involved phenomena (corrosion, wear and wear accelerated corrosion). Tailoring the implant to the specific patient will thus require for determining not only the biomechanics of the person (loading and kinematics during the movement), but also the chemical reactivity of the synovial fluid. The present talk will be focus on the strategies to determine the electrochemical reactivity of the synovial fluids in-vivo and their implications on the durability of joint prosthesis.