Due to the complex laser-material interactions, development of alloys specifically suited for AM is a challenging task. The integration of multi-scale, multi-physics experimental and computational methods, i.e. Integrated Computational Materials Engineering (ICME), in alloy design for AM is a promising approach to address this issue. Furthermore, ICME-based design provides a sustainable path towards alloy development compared with traditional trial-and-error-based approaches. For the development of novel high-performance alloys with superior operation temperature as well as creep and corrosion resistance, oxide-dispersoid strengthened (ODS) alloys manufactured via AM present a promising opportunity for high-temperature devices for aggressive environments. This study emphasizes the use of an ICME framework for the accelerated development of novel ODS alloys, highlighting the key Process-Structure-Properties-Performance (PSPP) relationships, by integration of multiple ICME tools. A Finite-Element (FE) model supported with material properties from Thermo-Calc presents the AM processing characteristics applied to the phase-field software MICRESS® and python to understand the process-structure relationship. In addition, the properties and performance are modelled through creep and tensile simulations. This enables to describe the entire manufacturing chain and the final product's performance when in service by closed and complete simulations. Thus, through applying these material models at multiple scales a novel ODS alloy design framework is established.