Developing strong and ductile alloys that have high resistance to hydrogen embrittlement is vital for constructing safety-critical hydrogen-based industries. However, when enhancing alloys’ strength levels, usually a fundamental issue is encountered, i.e., the increase of mechanical strength correlates with the decrease of resistance to hydrogen attack. This can be ascribed to that, the microstructure features of increasing strength (e.g., interfaces and second phase precipitates) are preferential sites for hydrogen accumulation, leading to hydrogen enhanced local plastic softening or decohesion. Therefore, it is important yet challenging to design alloys that exhibit excellent mechanical properties in the presence of hydrogen. Recent studies on the hydrogen embrittlement behavior of medium- and high-entropy alloys (MEAs & HEAs) have suggested that several MEA and HEA variants have lower hydrogen embrittlement susceptibility than the widely used stainless steels [1,2], suggesting a promising direction of designing hydrogen tolerant materials. In this talk, we will present the recent efforts on developing hydrogen resistant HEAs with excellent strength-ductility synergy. One work is about the interstitially alloyed HEA variants with tunable phase stability and hydrogen embrittlement resistance by controlling interstitial contents, where the crack propagation behavior can be adjusted from fully intergranular cracking to a mixture of both intergranular and transgranular cracking (Figure 1, Ref. 2). Another work is on a series of newly developed hydrogen-resistant HEAs with both low stacking fault energy (SFE) and short-range ordering (SRO). The coupling of low SFE and SRO enables the manipulation of stacking faulting behavior within grain interiors, relieving the intergranular cracking and enhancing the strength-ductility synergy in presence of hydrogen. A few other promising concepts for future studies of this topic will also be briefly discussed.