Nanoparticles (NPs) have diverse applications due to their unique properties, and Single Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS) is crucial for accurate NP analysis.

As the narrow peaks from single particles require fast data acquisition, Quadrupole-ICP-MS can generally only analyze a single element for SP measurements due to its sequential operating principle. However, CRC gases can significantly increase the signal peak width of particles and can allow dual-mass measurement of individual NPs using a quadrupole-based ICP-MS.

To address challenges with traditional SP-ICP-MS, solid sample analysis with laser ablation (LA) can be used, offering advantages for NP analysis. A proposed peak-broadening approach for multi-element SP-ICP-MS combined with LA sampling method was studied. These findings aim to contribute to the advancement of laser ablation SP-ICP-MS techniques.