Due to the advancements in four-dimensional (4D) printing technology, the manufactured components may now adapt their form, size, or defining features in response to the stimulus provided. In recent years, innovative 4D printing technology has permitted extensive applications in different areas of science, technology, and engineering. 3D Printing technologies have come a long way from rapid prototyping to mass customization. Fused filament fabrication (FFF) based 4D printing, employing shape memory polymers, is now a common and cost-effective option for creating shape-changing structures. It is well-known fact that a programming/ training approach is required for any shape memory material to display the shape memory effect. The work involves 4D printing of negative honeycomb and simple honeycomb 3D structures by FFF additive manufacturing. Two different programming strategies were applied to get a thermo- responsive shape morphing and strain recoverable behaviour in the structure. It is discovered that samples that were programmed during the printing process produced superior results because of the underlying mechanism of the printing process. The present findings show how additive manufacturing's design flexibility can be put to good use in the creation of structures whose characteristic properties may be modified immediately after being removed from the print bed. These results can be very useful for the economical, minimally invasive deployment of shape-changing biomedical scaffolds for bone tissue engineering.