Borates are ester compounds formed by the combination of boron with organic acids. The structure and properties of borates can vary depending on the type of organic acid they are combined with. Fructoborates, which contain fructose, boric acid, and a metal salt (such as potassium, sodium, magnesium, or calcium ions), can be used as dietary supplements for healthy bones and joints. Calcium fructoborate has gained attention as a dietary supplement due to its potential health benefits, particularly in reducing inflammation, and promoting overall well-being. [1,2] It helps to improve calcium absorption and retention in bones, making it beneficial for bone health and potentially preventing conditions like osteoporosis [1-3]. Additionally, calcium fructoborate supports the body’s metabolism and hormonal balance, as boron plays a key role in regulating sex hormones and enhancing the utilization of essential minerals like calcium and magnesium. Moreover, its unique structure enhances its bioavailability, allowing for better absorption and more effective use in the body. Overall, calcium fructoborate can provide significant benefits for bone and joint health, cardiovascular support, and overall vitality, making it a valuable supplement for aging individuals or those looking to improve their health.

In the present study, one of the borate esters, calcium fructoborate was synthesized to be used as active ingredient in food supplements. Trace analysis in calcium fructoborate supplements ensures the identification of potential contaminants, such as heavy metals, for purity and contamination control. Additionally, analyses were performed to verify whether the calcium and fructoborate ratios, which determine the supplement's efficacy, are accurate. Finally, trace analysis was conducted to check the products' compliance with health standards and regulations. The chemical measurements carried out in the study met the requirements of TS EN ISO/IEC 17025:2017, with trace element determination in calcium fructoborate performed using ICP-OES and/or ICP-MS instruments. The determined values and their associated uncertainties met the requirements of relevant standards and guidelines. The study involved calculations based on ISO 21748 Standard and Nordtest TR537 Measurement Uncertainty Calculations using intermediate precision data. The findings indicate that calcium fructoborate is suitable for use as an active ingredient in dietary supplements.

References

[1] G.D. Mogoşanu, A. Biţă, L.E Bejenaru, C. Bejenaru, O. Croitoru, G. Rău, O.C Rogoveanu, D.N. Florescu, J. Neamtu, I.D. Scorei, R.I. Scorei, Biological Trace Element Research, 2016, 172, 277-281.

[2] M.K. Al-Omari, M. Elaarag, R.M. Al-Zoubi, A.R Al- Qudimat, A.A. Zarour, E.A. Al-Hurani, Z.E. Fares, L.M. Alkharraz, M. Shkoor, A.D. Bani-Yaseen, O.M. Aboumarzouk, A. Yassin, A.A. Al-Ansari, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38, 1-16.

[3] M. Rondanelli, M.A. Faliva, G. Peroni, V. Infantino, C. Gasparri, G. Iannello, S. Perna, A. Riva, G. Petrangolini, A. Tartara, Journal of Trace Elements in Medicine and Biology, 2020, 62, 1-11.