The incorporation of nanoscaled particles into a ductile alloy matrix is commonly referred to as dispersion strengthening (DS). During laser powder bed fusion (LPBF), the accumulation of these nanoparticles along the interdendritic cell walls takes place and may result in superior mechanical performance in comparison to unmodified material. The reason for this is a suppression or obstruction of the dislocation movement, which significantly increases both, the ultimate tensile strength and the creep resistance. Feasibility of DS in the present NiCu-based Alloy 400 during LPBF was demonstrated for various modification routes already, e.g. based on (i) gas atomization reaction synthesis (GARS) and (ii) the addition of nanoparticles to the base alloy during the powder feedstock preparation process, respectively. The present work gives a broad overview of multiple DS modification processes for Alloy 400, not only highlighting promising ones, but also presenting the reason for drawbacks of unsuccessful processes. Nanoparticle incorporation into both powders and parts is characterized and evaluated. Ultimately, a determination of mechanical properties is carried out, leading to a decision on whether or not the particular modification route can be considered a potential candidate for DS enhancement of Alloy 400.