Cryogenic Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry is a technique that has gained attention for the analysis of biological tissues recently. Multiple works have demonstrated that cooling of the sample during the laser ablation process can:

1. improve the laser-sample interaction leading to enhanced spatial resolution
2. suppressing diffusion of mobile elements in the sample
3. make possible the analysis of samples that are liquid at room temperature.

Apart from the latter these effects should also apply to polymeric materials, but there is little literature that investigates the impact of cryogenic laser ablation (CLA) on this substance class. In this contribution we intend to investigate whether:

1. CLA can reduce thermal effects during the ablation of polymers
2. CLA leads to an improvement in signal stability compared to regular laser ablation
3. the water content of polymers has a significant impact on the ablation process