7th Euro BioMAT 2023 - European Symposium on Biomaterials and Related Areas
Lecture
03.05.2023 (CEST)
Alumina ceramic textiles as novel bacteria capturing wound dressings
DD

Dr. Deepanjalee Dutta

Universität Bremen

Dutta, D. (Speaker)¹; Brüggemann, D.²; Maas, M.¹; Rezwan, K.¹
¹University of Bremen; ²Hochschule Bremen - City University of Applied Sciences
Vorschau
22 Min. Untertitel (CC)

Ceramic textiles are well known for their use in high temperature applications. Due to their flexible, biocompatible, and inert nature they also have great potential for use in biomedical applications, particularly as dressings for wounds. Although ceramic substrates are often used as bone implants, they are generally mechanically too stiff to be used in soft tissues like skin. In this study, we focus on tricot knit alumina ceramic textile (Zircar Ceramics Inc., USA) as a new material for flexible wound dressings. We studied whether it can capture bacteria on its surface with the aim to reduce bioburden and prevent inflammation in wound sites. To study bacterial interactions with alumina textiles, cultures of E. coli and B. subtillis were incubated with the textiles and other commercial dressings on agar plates, in different configurations. This set up would allow to test for bacteria attachment and membrane penetration. After detaching the alumina textiles from the agar, optical density measurements with bacteria-incubated textiles that were resuspended in growth media and visual analysis of the agar growth plates revealed that only negligible numbers of bacteria remained on the agar surfaces. E. coli and B. subtilis were found to be captured on the surface of the alumina textiles, according to SEM experiments. These outcomes were compared with those of commercial dressings. The Cutimed Sorbact and non-woven gauze dressings were able to remove bacteria from agar surfaces and prevented bacterial penetration, but were less efficient compared to alumina textiles. The dressing made of woven gauze displayed the least activity in this regard. In conclusion, our findings imply that the alumina textiles are highly interesting candidates for use as bacteria-capturing wound dressings. Despite being an inorganic material, they strongly adsorb bacteria, and it will be very interesting to expand our studies to other microorganisms, also including multi-resistant strains, to create a comprehensive portfolio of the textiles’ antibacterial properties.

Abstract

Abstract

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