The micro- or nanoscopic fluidic networks found in nature, such as the lacuno-canalicular network (LCN) in bone, play vital roles in biological functions like fluid and nutrient transportation and physiological regulation. Microfluidic channels, potentially mimicking the LCN, offer opportunities for studying fluid flow dynamics. However, fluid flow in microfluidic channels is typically studied under static boundary conditions without considering the dynamics and responsive nature of the liquid channels. This load-induced fluid flow is believed to transmit information and perform biological functionalities. Therefore, exploring the relationships and potential programmable interactivities between external mechanical loads, matrix, and fluid flow is an intriguing approach to understanding the fundamental mechanisms of information transmission in venous architecture.  Here, we design an elastomeric microfluidic chip, inspired by the LCN in bone structure. Mechanical loading induces substrate deformation, changing the solid-liquid contact angle and initiating a pump-like effect for controlled unidirectional fluid flow. This provides insights into fluid dynamics influenced by mechanical stimuli.