The impressive progress made in the 3D printing field in recent years, has made possible the engineering of a myriad of new objects in a diversity of areas, including the medical devices arena. That said, only a new generation of 3D printed constructs, combining pioneering concepts and novel tailor-made materials will permit further progress. As derived from this conceptual framework and contrary to the vast majority of the 3D structures printed to date, which are static in nature, our work aims at engineering 3D printed responsive architectures. After briefly reviewing this expanding field, this lecture will focus on the tailoring of functional printable molecules (“inks”) that perform as the basic building blocks of the architectures printed. The “inks” to be introduced differ in their composition, morphology and mechanical properties, allowing the optimal design of personalized, multi-functional 3D printed medical devices. The emphasis will initially be allocated to imparting to the “inks” their diverse capabilities, including their UV-initiated printability, shape memory behavior, tunable biodegradability, reverse thermo-responsiveness and pH sensitivity. The ability to engineer custom-made medical devices and to implant them following minimally invasive procedures are two important trends in modern surgery. The personalization of the device is achieved by 3D printing it, while the capacity to deploy it minimally invasively harnesses the shape memory behavior displayed by the “inks” used. Capitalizing on the “inks” developed, two dynamic medical devices, one performing along the tracheobronchial tract and the other in the cardiac arena, will be presented.