Dry eye syndrome is currently the most prevalent eye condition, caused by insufficient lubrication by natural tear fluid. Due to prolonged discomfort and pain, dry eye symptoms force many contact lens users to stop using these devices. To prevent and treat this condition, we have developed at INM a living self-lubricating contact lens, consisting of a porous PVA hydrogel matrix containing biofactories of hyaluronic acid (HA), a natural lubricant that helps to retain moisture at the corneal surface and reduce the friction with the contact lens surface. In contrast to the existing ocular delivery systems, the developed living self-lubricating contact lens provide in-situ production and controlled, on-demand delivery of HA to the eye surface, thus constituting a sustainable alternative to eye drops for long-term eye lubrication.