Exploring a cutting-edge field of materials science and biomedical engineering, switchable antimicrobial materials emerge as a forefront domain with significant implications. Biomaterial associated infections (BAIs) often arise in the context of implants, presenting a substantial clinical challenge due to their recalcitrant nature, frequently necessitating implant replacement. The prevailing antimicrobial strategies predominantly hinge on static concepts. To address the limitations posed by static approaches, we investigate micro mechanical oscillation coupled with nano rough surfaces, seeking to unravel their impact on bacterial adhesion. Drawing insights from prior studies, which demonstrated reduced adhesion forces at nano-contact points on biomaterial surfaces, we comprehensively tested the influence of diverse nanotopologies, achieved by physical vapor deposition and surface etching, on the microbial adhesion. Our ultimate goal is to engineer switchable antibiotic free biomaterials, which enable to dynamically adjust antimicrobial actions.