Recent advances in the employment of plasmonic nanoparticles serve as the foundations for rapid progress in unusual classes of sensing technologies for medical applications.[1] The most sophisticated of such systems provide broad capabilities in continuous biophysical and biochemical monitoring of health status, in many cases with levels of precision and accuracy that can compete with clinical detection standards. In this work, we focus our attention on a class of biomedical devices based on textiles, whit the aim to convert them from inert material into sensors for the detection of infection and position. These polymer-based textiles (e.g., polypropylene (PP), polyurethane) are widely used in surgery due to their durability and long-term strength. [2] Unfortunately, there are some risks associated to their implantation, as flammatory reaction and motion, lacking good fixation. In our research group, we have recently designed PP-based meshes for hernia repair covered by a thermosensitive hydrogel (TSH) based on poly(N-isopropylacrylamide) (PNIPAAm), able to self-unfold during the implantation in the human body, working as a 4D actuator under temperature stimulus. [3] The step forward in this appealing investigation is the conversion of the actuator to a sensor able to detect position and infection by means of the surface enhanced Raman scattering (SERS) technique. [4] For this, the textile-g-PNIPAAm material has been modified with different kinds of metal nanoparticles (based on Au, Ag, MgO), in order to enhance the intensity of the Raman signal coming from a reporter molecule (RaR) attached to their surface, and then used for the monitoring of the health status. This work opens new frontiers to semi-invasive diagnosis of surgical implants and artifacts made of polymer, by using SERS spectroscopy.