Bioadhesives are materials that can adhere to both hard and soft tissues. Bioadhesives can be used as wound dressings and
tissue sealants. Bioadhesives are highly favored due to their ease of use and rapid application (injectable hydrogels) to close
surgical sites. In cases such as chronic wounds, it is vital to choose an optimum hemostatic bioadhesive that is antibacterial and
can track and record physiochemical and physiological changes in the wound to prevent infection. Here, we developed pH-sensitive
hybrid hydrogel-based adhesives based on chitosan and alginate, containing different concentrations of silver-tannic
acid nanoparticles. The hybrid hydrogels based on chitosan and alginate were mixed with the different concentrations of
functionalized silver nanoparticles. The adhesive, antibacterial properties, and pH-responsiveness of the blend hydrogel were
evaluated. Reversible Schiff-base linkages between amino groups on carboxyethyl chitosan (CEC) and aldehyde groups on
oxidized sodium alginate (OSA) and ionic cross-linking between Ca2+ ions and carboxyl groups on OSA were used to create
the injectable multifunctional wound dressing hydrogel. Functionalized particles were used as a pH-responsive indicator as
well as an antibacterial agent in this method. The hydrogels showed that as pH varied from 3.0 to 9.0, the color changed from
red to green. Furthermore, the adhesion characteristics in the presence of particles were higher (28 kPa) than in pristine
hydrogel. They further showed self-healing properties with high cytocompatibility with human fibroblast cells. The porous
structure and the hemostatic impact of CEC and tannic acid demonstrated that the hybrid hydrogels can present an excellent
hemostatic performance with a shortened in vitro blood clotting time. Moreover, hybrid gel with functionalized silver particles
showed a good antibacterial effect on the growth rate of E. coli and S. aureus. In conclusion, these hydrogels have the potential
to be good wound-dressing hydrogels for both wound healing and pH monitoring.