Exploration of novel metallic alloy systems such as high entropy alloys (HEAs) and related compositionally complex alloys (CCAs) is normally a time consuming and cost intensive process. In order to enhance the effectiveness of alloy development a combinatorial high-throughput screening approach based on CALPHAD simulations and experimental validation has been developed and utilized. This technique enables a rapid alloy development within a wide compositional range and automated fabrication of graded components with varying chemical composition and microstructure. Enhanced by semi-automated analytical characterization of the produced samples, this approach facilitates the design of novel CCAs with promising properties for specific requirements