The maritime sector, energy business or chemical processing – Alloy 400 can be found throughout various industries that require outstanding high-temperature properties of the material used, e.g., in carburizing (metal dusting) atmospheres. To further enhance the performance of an alloy system under such circumstances and to thus make it long-lasting in aggressive environments, current efforts in additive manufacturing (AM) are aiming at modifying materials with ceramic nanoparticles. The dispersion strengthening effect intends to result in superior mechanical characteristics due to dislocation motion suppression. In this work, the NiCu-based Alloy 400 is strengthened via the implementation of TiN dispersoids on the nanoscale. The presented approach considers the modification of both, powders for laser powder bed fusion (LPBF) as well as the parts manufactured of these. During AM, characteristic microdendritic cell structures result with nanoparticles aligning along sub-grain cell walls. A holistic process route for nanoparticle reinforcement, based on multiple modification routines, is presented and consisting of: (i) powder production via gas atomization, (ii) powder characterization, (iii) powder processing during LPBF and process parameter optimization, (iv) part characterization and (v) testing.