MSE 2022
Lecture
27.09.2022
Anti-biofilm bioresorbable polyester coatings in glass and titanium based medical devices.
DZ

David Zermeno Perez (M.Sc.)

Ashland Specialties Ireland Ltd.

Zermeño Pérez, D. (Speaker)¹; Chouirfa, H.¹; Duffy, P.¹; Greiser, U.¹; Wang, X.¹; Ó'Cróinín, T.²
¹Ashland Specialties Ireland Ltd., Mullingar (Ireland); ²University College of Dublin
Vorschau
20 Min. Untertitel (CC)

Implant associated infections, commonly caused by biofilm-forming bacteria end in 70-80% implant rejections that are highly problematic for the patient and the healthcare system. Poly(D,L-lactide-co-glycolide) (PLGA) and Poly(D,L-lactide) (PDLLA) are well studied and approved bioresorbable polymers (BRP) for biomedical applications. Polyethylene glycol (PEG) is known to have antifouling properties due to his hydrophilic nature forming a hydration layer in coatings with enhanced mechanical flexibility and wettability. Silver Sulfadiazine (AgSD is a broad-spectrum antibacterial with similar mechanism of inhibition as silver nanoparticles, with known antibacterial activity in 0.5-2% concentration, it has a wide array of applications in wound healing and protection of medical devices, we propose a novel AgSD-loaded Pegylated polymer coating to prevent the biofilm related infections in dental and orthopaedic implants. 

Abstract

Abstract

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