Ashland Specialties Ireland Ltd.
Implant associated infections, commonly caused by biofilm-forming bacteria end in 70-80% implant rejections that are highly problematic for the patient and the healthcare system. Poly(D,L-lactide-co-glycolide) (PLGA) and Poly(D,L-lactide) (PDLLA) are well studied and approved bioresorbable polymers (BRP) for biomedical applications. Polyethylene glycol (PEG) is known to have antifouling properties due to his hydrophilic nature forming a hydration layer in coatings with enhanced mechanical flexibility and wettability. Silver Sulfadiazine (AgSD is a broad-spectrum antibacterial with similar mechanism of inhibition as silver nanoparticles, with known antibacterial activity in 0.5-2% concentration, it has a wide array of applications in wound healing and protection of medical devices, we propose a novel AgSD-loaded Pegylated polymer coating to prevent the biofilm related infections in dental and orthopaedic implants.
Abstract
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