Laser surface structuring and especially direct laser interference patterning (DLIP) has proven to be an excellent tool to tailor the interaction of surfaces with surrounding media or organisms like bacteria or cells [1–3]. Chemical alterations of the surface caused by the laser processing are often seen as an undesired side effect as they mask the substrate material and its intrinsic properties. This work presents a novel approach that focuses on the possible positive effect of process oxide produced in the DLIP processing of titanium surfaces. DLIP process parameters were optimized to produce a highly porous oxidic structure in addition to the periodic DLIP pattern. As this oxidic layer consists of a variety of Titanium oxide phases the produced surfaces show photocatalytic activity under UV-A light which could enable respectively treated implants and prostheses to kill bacteria and remove pollutants. SEM/FIB and XRD investigations show that the morphology and composition of the hierarchical oxide layers can be controlled through distinct variation of laser parameters. Especially the combination of the different TiO2 allotropes Rutile and Anatase has proven to be an effective way to produce photocatalytically active materials like the commercial Degussa p25 nanoparticle powder [4–6]. The presented single-step production of photocatalytically active surfaces consisting of various titanium oxides therefore presents a significant improvement over traditional multi-step approaches including nanoparticle synthesis and subsequent surface coating.