Precipitation strengthened Nickel base Superalloys exhibit significant strain localisation when deformed plastically. Investigating strain localisation at the nanoscale is particularly interesting because the link between the evolution of strain localisation, the strain hardening behaviour and crack initiation is poorly understood. In this study, in-situ monotonic tensile experiments were conducted in a Scanning Electron Microscope using a specifically designed loading rig with an integrated software interface that enables automated tracking and large area image capture for a region of interest (ROI) at high resolution. Additionally, automated capture provides measurements with high temporal resolution allowing the very first slip trace in the ROI to be identified and its slip evolution to be quantified. Furthermore, loading in small strain increments and capturing many grains allows the orientation, twinning and slip transfer across grain boundaries (GBs) to be fully characterised in the elastic region, at the onset of plasticity and in the early stages of plastic deformation. The displacement calculations for each loading step were calculated using LaVision DaVis 8.4.0, a commercial DIC software package. The strain calculations and data analysis were performed using the in-house developed and open source DefDAP Python package. These routines enable the orientation maps captured by orientation mapping to be directly linked to the strain maps in terms of position. Combining the two datasets allows detailed analysis to be performed on a grain-by-grain basis.This study highlights the improved understanding that can be gained on the evolution of strain localisation by employing the in-situ HRDIC technique.