Medical device-associated infections compromise the longevity of prosthetic implants. Microbial biofilms, which form on the implant surface, are among the main causes of recalcitrance of such peri-implant infections. Therefore, there is a growing interest in strategies to discourage microbial colonization and biofilm formation on an implant surface. Immobilization of antimicrobial compounds by covalent bonding to the surface offers advantages over simpler methods like physical adsorption or entrapment in degradable coatings, as this enhances the stability of the compound under physiological conditions as well as during implantation. However, reaching a therapeutically active threshold concentration of antimicrobial compounds at the implant surface via immersion is a time-consuming process, as it depends on the passive diffusion of the compounds to the surface. We have developed a technology to actively concentrate the antimicrobial compounds at the implant surface by means of alternating current electrophoretic deposition (AC-EPD). Applying alternating current fields (with an asymmetric wave shape) enables electrophoresis of charged compounds in aqueous suspensions towards the implant surface, significantly improving the immobilization yield without compromising the biological activity of the compounds. A proof-of-concept was established for various compounds, thereby effectively imposing antimicrobial resistance against multiple pathogens onto titanium implant surfaces.