Oxide dispersion strengthened (ODS) alloys, featuring nanoscale oxide particles uniformly dispersed within a metallic matrix, are pivotal materials driven by technological advancements necessitating enhanced material strength and elevated temperature creep resistance. Traditional manufacturing routes for ODS parts via powder metallurgy involve complex steps. Powder-based Additive Manufacturing (AM) offers a promising avenue for ODS material production, enabling near-net-shaped production directly from tailored powder materials, thereby significantly streamlining the manufacturing process. However, the combined application of ODS alloys and AM has yet to be scaled up for industrial use, particularly for aggressive high-temperature environments with demanding mechanical operational requirements. This presentation focuses on developing novel nanostructured metallic materials, specifically nano-oxide/nitride-dispersoid strengthened high-temperature alloys based on Fe, Ni, and NiCu, suitable for additively manufactured gas burner heads and high-temperature heat exchanger components. The approach integrates advanced material simulation tools like integrated computational materials engineering (ICME) and artificial intelligence (AI) methodologies, including neural networks, for optimized alloy, component, and process design. The key aspects include implementing a new processing route integrating nanotechnologies for powder modification and AM through laser powder bed fusion (LPBF). This holistic approach aims to enable the practical application of ODS alloys in combination with AM in real-world industrial settings, meeting the stringent requirements of aggressive high-temperature environments and challenging mechanical operational demands.