Recently, various hydrogen carriers, such as liquid hydrogen and organic hydrides, have been investigated due to their lower volumes compared to hydrogen gas. In particular, research has focused on the application of larger-diameter valves for liquid hydrogen. This has led to the consideration of new cast alloys with excellent resistance to hydrogen embrittlement (HE) as a viable option, considering both the machining processes and the potential for reducing the cost of hydrogen-related components. From this perspective, our previous study demonstrated that Cu-Al-Ni-Fe-Mn cast alloys, which exhibit higher tensile strength (TS) compared to nickel-equivalent materials (typical TS of 550 MPa) and Type 304 stainless steel (typical TS of 620 MPa), show excellent resistance to HE, as confirmed by slow strain rate tensile (SSRT) testing. In this study, SSRT tests were performed at temperatures ranging from low to room temperature (RT), and fatigue-life tests were conducted at RT for both uncharged and hydrogen-charged Cu-Al-Ni-Fe-Mn cast alloys. The alloys correspond to CAC702 and CAC703 in JIS-H5120, with typical TS values at RT of 620 MPa and 700 MPa, respectively, which are not specified in the standard. The hydrogen-charged alloys were prepared by exposure to 100 MPa hydrogen gas at 270°C for 200 hours. The dissolved hydrogen reached saturation, with a concentration of at most 3 wt.ppm, which is considerably lower than that of conventional austenitic stainless steels, such as Type 304 and Type 316 (around 100 wt.ppm). A series of tests was conducted to investigate the applicability of these alloys for hydrogen service. SSRT tests were carried out at an initial strain rate of 5 × 10⁻⁵ s⁻¹, and no degradation in tensile ductility was observed from -196°C to RT. Fatigue tests of both uncharged and hydrogen-charged smooth specimens containing an artificial defect were conducted using a rotating-bending fatigue tester at a stress ratio of -1 and a test frequency of 10 Hz. The results revealed no reduction in fatigue life or fatigue limit due to hydrogen. Furthermore, the absence of hydrogen-induced reduction in fatigue life suggests no acceleration of fatigue crack growth rate (FCGR) by hydrogen. FCGR did not increase in the presence of hydrogen, even at a test frequency of 0.1 Hz. These results demonstrate that Cu-Al-Ni-Fe-Mn cast alloys possess excellent resistance to HE in terms of both tensile and fatigue properties.