Metallic alloys with high strength and large ductility are highly required for a wide range of advanced structural applications. However, the increase of strength often results in a substantial decrease in ductility. In this talk, we present a new strategy to address the strength-ductility trade-off of high-entropy alloys through dual precipitation. High number densities of nano-sized precipitates provide a very effective strengthening effect to improve the yield strength, whereas a proper amount of coarse-sized precipitates improves the work hardening capacity through strong pinning of dislocations. As a result, the newly developed alloys exhibit a yield strength of 1.4 GPa, a tensile strength of 1.6 GPa, and a ductility of 20%, demonstrating a good combination of high strength and ductility. The contributions of the nano- and coarse-sized precipitates to the strength are quantitatively analyzed, and the relationship between precipitate microstructures and mechanical properties of the dual-precipitation-strengthened HEAs are critically discussed. The superior mechanical properties of the dual-precipitation-strengthened HEAs offer tremendous potential for structural applications in aerospace, automotive, and energy industries.