In house developed meso scale test rig were utilized to understand the accumulated strain evolution in the Ti-6Al-4V alloy upon tensile and fatigue loadings. Samples featuring a gauge section ~200 microns in width, ~120 microns in depth, and ~300 microns in length were prepared using femtosecond laser micromachining. High-resolution digital image correlation (HR-DIC) combined with electron backscatter diffraction facilitates a quantitative analysis of heterogeneous in plane strain evolution across the entire gauge section, which enables the tacking of crack nucleation and short propagation, as well as the analysis of localized strain fields ahead of the crack tip. Such a in situ meso scale experimental approach provides a fundamental understanding of crack initiation and propagation mechanism.