Half-metallic ferromagnetic alloys are attracting considerable interest for their potential applications in spintronic devices. Since the development of spin-voltage generators is regarded as crucial in spintronics, thermoelectric properties are also of high interest for such technology, having been proved spin-Seebeck effect to be an effective way to generate and carry spin-polarized current over relatively long distances. Co-based Heusler alloys are considered to be among the most promising classes of half-metallic compounds as they combine suitable magnetic, electronic and transport properties with compositional versatility and high thermal stability and are greatly looked after. For this contribution, we investigated the transport properties of a promising alloys for such applications, namely Co2ZrSn Heusler compounds combining experimental and ab-initio calculations. Different processing routes were found to lead to different structural and microstructural features that affects electronic and thermal transport. The samples processed by spark-plasma sintering of melt-spun powders show a remarkably finer microstructure with respect to arc-melted ingots, suppressing thermal conductivity and increasing the figure of merit ZT.