In the last decade, multi-signal calibration methods have been proposed as simpler and faster alternatives to correct for both physical and matrix interferences. However, the calibration curves for MEC, MICal, MSC, and MFC are based on the use of signal intensities on both axes, therefore the setting of the x-axis is not possible as observed for traditional methods where concentrations may be changed. In these cases, uneven distribution of points may occur and, when a sensitive emission line or abundant isotope/specie is used in calibration, influent and leverage points can be observed. In this work, a case study for the determination of Ti by ICP-MS using MICal was proposed to evaluate how influent and leverage points can affect multi-signal methods. Quantitative recoveries were impaired for relative errors in the leverage point higher than 5%, thus showing the importance to monitor these points in multi-signal calibration methods.