During the last twenty years, infectious diseases have emerged as one of the greatest threats to public health worldwide [1]. Despite the recent discovery of new antibiotics, the improper administration of antibiotics over the years has led to the development of multidrug-resistant strains [1]. Additionally, conventional drug delivery systems are known for their low bioavailability and reduced efficacy [2]. In order to overcome these limitations, novel controlled drug delivery systems based on mesoporous bioactive glass nanoparticles (MBGNs) and phytotherapeutic agents are being increasingly developed [3]. The ions released from the MBGN structure together with the release of the phytotherapeutic agent could synergistically enhance the therapeutic effect. Thus, the purpose of this study was to develop and assess different compositions of MBGNs as nanocarriers for gallic acid (GA) as phytotherapeutic of choice, to achieve nanosystems with enhanced antibacterial activity.

[1] M. Frieri, K. Kumar, and A. Boutin, J. Infect. Public Health, 2017, 10, 369–378.

[2] S. Adepu and S. Ramakrishna, Molecules, 2021, 26, 19.

[3] K. Ilyas, L. Singer, M. A. Akhtar, C. P. Bourauel, and A. R. Boccaccini, Pharmaceutics, 2022, 14, 126.