Iron (Fe) is considered as an impurity element in aluminum alloys (Al) due to its good solubility of more than 2.5 wt.% (at 700 °C). During solidification, Fe mainly forms a coarse, plate-like phase (β-Al4.5FeSi), which has a detrimental effect on mechanical and casting properties. Therefore, the objective is the reduction of Fe in Al alloys, using a two-step process technology of conditioning and metal melt filtration. In this study, the influence of chemical composition and temperature control on the reduction of Fe was investigated for an industrial filtration application. Based on the cooling curves in dynamic difference calorimetry (DSC), the temperature regimen of the filtration process was adjusted to the formation of the primary solidifying Fe-rich phases. The implementation of a two-step separation process was performed using a filtration device on industrial scale (≈100 kg). The ceramic foam filters of size 7'' were examined by optical microscopy and scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS) to obtain insights on the deposition characteristics of the Fe-containing intermetallics. A distinct filter cake of Fe-rich intermetallic particles was detected by conditioning the melt using the elements manganese (Mn) and chromium (Cr). Without these elements, merely oxides and β-intermetallics appeared on the filter surface. The results in the optical emission spectrometer revealed a reduction of the elements by approximately 41% (Fe), 45% (Mn), and 60% (Cr) from initially 0.866 wt.% Fe, 0.78 wt.% Mn, and 0.72 wt.% Cr.