The present work evaluates the tribological performance of a self-lubricating nickel-based coating during sliding contact against aluminum (AA 6082) and titanium (Ti6Al4V) alloys. The microstructure and phase composition of the deposited self-lubricating alloy is characterized using X-ray diffraction, scanning and transmission electron microscopy. Afterwards, its friction and wear performance against aluminum and titanium is evaluated at room temperature and at 300 °C. The experiments are performed using a load scanner tribometer in a single passe configuration in order to mimic the conditions found in forming processes, covering a load range from 50 to 400 N. The results show that the self-lubricating coating is able to provide better frictional control when compared to a tool steel used as reference, independently of the amount of lubricant applied. Further, the use of a self-lubricating coating results in a reduction of adhesion, particularly at elevated temperatures, thus making it an excellent candidate for high temperature metal forming operations in automotive and aerospace.