Calcium silicate (CS) based dental cements have enjoyed unparalleled success as materials for various vital and non vital pulp procedures (1). They are unique because of the sealing ability arising from apatite formation, biocompatibility and ability to set in a moist oral environment. Despite this, they are still being investigated extensively to optimize properties related to handling, rheology, mechanical properties and antimicrobial effects (2,3). Mesoporous bioactive glass nanoparticles (MBGNs) have emerged as exciting materials with enhanced surface reactivity and pores that can be loaded with ions or drugs (4). At the same time, lithium has been shown to enhance odontogenesis. We speculated that by combining these compounds to formulate water based calcium silicate cements (CSC), some of the drawbacks associated with the traditional cements could be reversed, hence provide a rational basis for introduction of novel CSC compositions. The aim of this project was to investigate how the addition of MBGNs, lithium doped MBGNs or lithium carbonate (LiC) affects the properties of CSC. Either of the 3 additives at 10% by weight, was added to a premixed blend of CSC and 30% zirconium dioxide. The blend also acted as the control material. The various samples were investigated in terms of setting time, flowability, film thickness, compressive strength, dissolution and biological behaviour. Based on the experimental results, the setting is significantly affected by LiC, but not by the MBGNs. However the flowability and film thickness was improved and the bioactivty appeared to benefit from synergistic apatite formation by CS, MBGN and Li C. There is potential to enhance antibacterial properties even further by doping the MBGNs with drugs or essential oils prior to incorporation into the experimental dental cements.