University of Debrecen
Cellular materials have many known applications, from aerospace technology to food production and pharmaceuticals. There is a wide range of beneficial applications for the user of this type of structure. The pharmaceutical industry has also recognised the benefits e.g. low density, buoyancy, carrier and drug volume reduction, controllable drug delivery, extended residence time, matrix material type. Low density floating formulations can increase gastric residence time of the drugs; therefore the drug release will be sustained. Our aim was to produce stable floating formulations by foaming. The main criterion for the selection of matrix was minimal irritation and a natural plant source was an additional consideration. Firstly, we used polyethylene glycol, and plant-derived polysaccharide: agar agar. Another option was to produce a swelling mould that swells in the stomach to ten times its original size so that it does not escape from the stomach, thus increasing the residence time. In this case the matrix was carrageenan. The produced solid foam was dried to reduce its size considerably, making it easy to dose. According to our experiments a stable foam could be produced by rapid homogenisation (shorter than 1 minute) without any surfactant material.
Abstract
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