In-situ SEM deformation experiments utilizing digital image correlation demonstrate that microstructural strain localization events exhibit a variety of micro-level strain paths. For example, micro-level local strain paths ranging from uniaxial tension to plane-strain tension can be seen in a single material when the macroscopically imposed strain path is the former. These varying strain paths point to the important role that shear deformation plays in the observed surface strains. For a better understanding of the proposed relations between localization direction and shear plane orientation, we here present integrated experiments combining in-situ SEM deformation experiments with analysis of the activated slip systems. Based on these results, further insights into the distribution of microscopic strain localizations are discussed. Furthermore, we present experiments using a custom-designed bulge test setup enabling us to comment on the influence of multiaxial loading conditions on the microstructural strain path development. Ultimately, this study leads to an enhanced understanding of the orientation and the distribution of microscopic strain localizations in metals.