A vast majority of the engineering components used for high-temperature applications contain cut sections, holes, notches, and cooling channels. These geometrical features create regions of stress concentrations and multiaxial stresses critical to the durability of these components. It is, therefore, essential to better understand the effect of multiaxial stresses on mechanical responses and lifetime. Creep tests on notch specimens were performed at 1050°C and different nominal stresses on the MC2 Ni-based single-crystal superalloy. Microstructural observations were performed to characterize the stress redistributions in the notch area and damage-coupled crystal-plasticity finite-element simulations were carried out to understand the effects of notch multiaxiality on lifetime.