With the development of high-strength steels, hydrogen embrittlement has been recognized as a severe problem in applications. It leads to hydrogen-induced premature failure of materials and unexpected catastrophe of structural components. The hydrogen embrittlement occurs across a wide range of metals and steels with different microstructures, with a particular susceptibility of high strength steels. To understand the mechanisms of hydrogen embrittlement and manage this issue are significantly important for the applications of these materials. Along with the progressive research and development of advanced high strength steels, e.g. high-Mn and medium-Mn steels, a multiscale approach combining theoretical simulations and experiments has been proposed towards the understanding and management of hydrogen embrittlement. Across the length scales from Å to mm, various hydrogen-related features have been investigated. Several case studies on hydrogen embrittlement in high-Mn and medium-Mn steels will be further discussed.