Gold nanoframes (GNFs) are a unique class of gold nanomaterials with a three-dimensional structure that is fabricated through chemical synthesis to form an open-framework structure. This special framework endows gold nanoframes with a large surface area, high porosity, and excellent mechanical strength, making them ideal for applications in surface-enhanced Raman scattering (SERS) catalysis reactions. These properties are particularly valuable for biomolecule detection and disease diagnosis, and gold nanoframes show significant potential for advancing these fields. 

In this study, octahedral gold nanoparticles were used as sacrificial templates, and a composite structure of a gold octahedral core with a Pt octahedral framework was successfully synthesized through a sequential edge-selective Pt deposition process. Subsequently, a larger gold nano octahedron was grown on the composite structure, forming flattened surfaces and sharp edges via the Frank-van der Merwe (FW) mode. The second layer of the Pt framework was further grown by edge-selective deposition, with Pt being deposited onto the edges of the gold nano-octahedron to form a second octahedral Pt framework. Finally, selective etching of gold resulted in Pt octahedral double-layer nanoframes with a highly uniform size and shape. 

To enhance plasmonic properties, gold was coated around the Pt frame, significantly improving its ability to capture light. The resulting plasmonic double-edge-sculpted nanoframes exhibited strong light-capture properties. Raman microscopy was employed to capture the signals of specific molecules when using gold nanoframes, achieving high sensitivity and selectivity in detecting target biomolecules. This provides strong technical support for the early diagnosis of diseases.

This synthesis method allows for the adjustment of the gap size and dimensions of the gold nanoframes. This provides potential applications in optics, catalysis, and other fields and offers a novel strategy for designing high-performance plasmonic nanoframes.