Geochemistry involves the study of Earth's chemical composition, processes, and history through the analysis of various types of samples, including rocks, minerals, fluids, and gases. Traditionally, these samples have been studied using a range of destructive and non-destructive techniques. However, demands in geochemistry have placed significant emphasis on in-situ analysis, which allows for the examination of samples in their natural state with minimal preparation. This shift is driven by the need for high spatial resolution and the ability to analyze minute areas or inclusions within complex geological matrices. In-situ methods encompass not only elemental analysis through techniques such as LA-ICP-MS and SIMS but also structural characterization, microanalysis, and isotopic ratio determination. Techniques like EPMA, Raman spectroscopy, and others provide critical insights into the mineralogical, crystallographic, and isotopic composition of geological samples. The integration of these in-situ techniques is crucial for obtaining a more complete understanding of geochemical systems, enabling more precise and localized analysis while preserving the integrity of the samples.