Zn, a biodegradable metal, exhibits immense potential as a bioresorbable implant material due to its remarkable biocompatibility and superior corrosion resistance in comparison to Mg. Nonetheless, the limited mechanical strength and hardness of Zn have significantly hindered its widespread application. To address this challenge, the incorporation of alloying elements has been explored as a strategy to enhance its mechanical properties. The objective of this study was to enhance the mechanical and corrosion resistance of Zn-1.5Mg-0.5HA-xMn (x=1 and 1.5 wt.%) alloys through rolling and investigate the impact of Mn additions on the material properties of Zn composites. The results from X-Ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FE-SEM) analyses showed that the rolled Zn-1.5Mg-0.5HA-xMn alloys demonstrated a buildup of intermetallic Mg2Zn11 phases along the grain boundaries. This accumulation is responsible for initiating particle-stimulated nucleation. The prepared sample (rolled Zn-1.5Mg-0.5HA-1.5Mn) shows very high Ultimate tensile strength (UTS 209 MPa) and hardness (103 HV). In a Phosphate Buffered Saline (PBS) solution, the corrosion and degradation rates of hot-rolled (HR) Zn-1.5Mg-0.5HA-1.5Mn alloys show a consistent reduction as the content of Mn increases, reaching a rate of 0.032 mm/year. The reduction in corrosion rate after rolling is primarily due to microstructural modifications, such as grain refinement, increased dislocation density, and a more homogeneous distribution of alloying elements The cultured MG63 cells demonstrated high viability when exposed to diluted extracts (25% and 50% extract) of the HR Zn-1.5Mg-0.5HA-1.5Mn sample for Day 1 to Day 5. In both cases, the viability exceeded 80%, indicating the absence of any potential cytotoxic effects. These findings highlight the biomedical suitability of the HR Zn-1.5Mg-0.5HA-1.5Mn sample for various applications, as it does not pose any harmful effects on cellular health.