Within the realm of nuclear forensics, safeguards, and nonproliferation, the ability to determine actinide (e.g., U and Pu) content and the respective isotopic abundances (e.g., 235U/238U, 234U/238U) in various sample matrices is critical. The detection of such target analytes, in low abundance, within a complex matrix, is the typical “needle in a haystack” problem. Regarding elemental / isotopic analysis, a traditional bulk analysis approach will ultimately homogenize the results leading to possibly a misinterpretation of respective processes. Being able to directly characterize the sample, for particles, can provide a more comprehensive understating of such sample. Here, recent develops in the realm of single particle analysis, which a focus on the nuclear analytical chemistry space, will be discussed. More specifically, the ability to introduce single particles (on a substrate, or in a suspension) into the ICP-MS. An emphasis will be placed on the exploration of multiple ICP-MS platforms including TOF- Quadrupole-, and multi-collector-based measurements.