Backflow in local injection therapy affects drug delivery efficiency, often leading to unpredictable therapeutic outcomes and suboptimal absorption of injected materials. Gelatin-based formulations offer an innovative approach to controlling viscosity and minimizing leakage, addressing a critical challenge in precise localized drug administration. This study evaluates the influence of gelatin particle size and hydrolyzed gelatin concentration on backflow reduction and injection precision.

A series of formulation tests was conducted to analyze the effects of gelatin structure, concentration, and particle size on fluid control during local injection. Additionally, injection parameters such as volume and needle gauge were assessed to further optimize viscosity and flow behavior for improved drug delivery efficiency. Results indicate that smaller gelatin particles significantly enhanced injection retention at lower concentrations, effectively reducing backflow rates in comparison to standard formulations. Moreover, higher molecular weight gelatin demonstrated superior fluid control, requiring lower concentrations (7-8%) for optimal injection efficiency.

These findings highlight gelatin’s ability to provide mechanical stabilization during injection, offering a promising solution for enhancing precision in local drug delivery applications. By optimizing gelatin-based formulations, this study contributes to the development of advanced biomaterials for controlled drug release, with potential implications in tissue engineering and regenerative medicine.